Tom’s take-

David Sinclair wrote a masterful book that covers so much ground it is amazing.  I wanted to share just a couple of the reviews both from the book cover and from Amazon.

• “An elegant and exciting book that deserves to be read broadly and deeply.”  Siddhartha Mukherjee, Pulitzer Prize-winning and #1 New York Times best selling author
• “Lifespan gives us hope for an extraordinary life…Enjoy this must-read masterpiece!”  Peter H. Diamandis, MD, founder and chairman of XPRIZE; executive founder of Singularity University; and New York Times best selling author of  ‘Abundance and Bold’
• 

  Timothy D. Lundeen
  5.0 out of 5 starsAll about healthy life extension, by a leading scientist

  September 17, 2019

  Format: Kindle Edition Verified Purchase
  . David makes three critical points:
  * longer healthy lifespan improves all of our lives, not just personally, but for all of the people we love
  * mechanisms to increase lifespan are part of our cells and often just need to be activated
  * increasing healthy lifespan will not make the world overcrowded, but will benefit everyone by increasing productivity and overall well-being
  All of these are well-supported and convincing, including touching and memorable personal experiences.I do have one major issue, though. Our current medical system is focused on the bottom line, making money is more important than the best protocol. Look at Vioxx, for example, which killed thousands of people so that Merck could make more money. David has personal experiences with the system: his Mom almost died from poisoning by prescription medicine, and his daughter could have died from a serious Lyme infection that was not properly handled.

  Yet David accepts that vaccination is a medical miracle, without doing any research on its risks and benefits. I hope he will take a serious look at all the issues:
  * the extremely high rates of chronic illness in vaccinated vs non-vaccinated children, The Children’s Health Defense has a good series based on peer-reviewed research
  * the connection between aluminum and autism, with artists having the highest levels. See Dr Chris Exley’s peer-reviewed work. Most vaccines have high levels of aluminum that has been shown to stay in the body and migrate to the brain
  * the connection between vaccination-induced brain inflammation and brain injury, see vaccine papers dot org, which includes full-text copies of peer-reviewed research: “powerful scientific evidence has emerged indicating that vaccines cause brain injury such as autism, epilepsy, schizophrenia, depression, attention-deficit disorder and other mental illnesses. This scientific evidence has been largely ignored by the media, and by medical institutions that are supposedly guided by science.”
  * the actual history of vaccination. Medical historians estimate that ALL of modern medicine, including vaccination and antibiotics, reduced childhood mortality by 4-6%. That is, 94-96% of the reduction was from improved sanitation and nutrition. For example, scarlet fever has been eradicated — without any vaccine. A good source is the book Dissolving Illusions.
  * the actual contents of vaccines as analyzed by Corvelva, showing high levels of contamination
  * the lack of liability for vaccines by the medical industry. Instead, a government fund compensates injuries, and has paid out over $4 billion. This does not motivate safer vaccines!
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“What do I do?” David Sinclair’s daily plan-

• I take 1 gram (1,000 mg) of NMN (Sandy and I do this now as well) every morning, along with 1 gram of Resveratrol (shaken into my homemade yogurt) and 1 gram of Metformin
• I take a daily dose of vitamin D, vitamin K, and 83 mg of aspirin
• I strive to keep my blood sugar, bread and pasta intake as low as possible. I gave up deserts at age 40, although I do steal tastes
• I try and skip one meal a day or at least make it really small. My busy schedule almost always means that I miss lunch most days of the week
• Every few months, a phlebotomist comes to my home to draw my blood, which I have analyzed for dozens of biomarkers. When my levels of various markers are not optimal, I moderate them with food or exercise
• I try to take a lot of steps each day and walk upstairs, and I go to the gym most weekends with my son, Ben; we lift weights, jog a bit, and hang out in the sauna before dunking in an ice-cold-pool
• I eat a lot of plants and try to avoid eating other mammals, even though they taste good. If I work out I will eat meat.
• I don’t smoke, I try to avoid microwaved plastic, excessive UV exposure, X-rays, and CT scans
• I aim to keep my body weight or BMI in the optimal range for health span, which for me is 23-25 Pg 304

More funding for the kind of research happening in my lab and others like it could bring about these advancements even sooner.  But because of a lack of funding, people over the age of 60 may not live long enough to be helped.  If you and your family members end up the last of humanity to live a life that ends all to early with decay and decrepitude, or our children never see the benefits of this research, you can thank those bioethicists.  Pg 301